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Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo
BACKGROUND: The clinical use of immunotoxins (ITs) has been hampered by hepatotoxicity, and the induction of a strong human-anti-IT response. The human-anti-IT response results in neutralisation of the immunoconjugates, rendering repetitive treatment inefficacious. METHODS: We evaluated the combinat...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768448/ https://ncbi.nlm.nih.gov/pubmed/19773757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605312 |
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