Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21(WAF1/CIP1) expression in ovarian cancer

BACKGROUND: Loss of growth inhibitory response to transforming growth factor-β (TGF-β) is a common feature of epithelial cancers. Recent studies have reported that genetic lesions and overexpression of oncoproteins in TGF-β/Smads signalling cascade contribute to the TGF-β resistance. Here, we showed...

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Detalhes bibliográficos
Main Authors: Chan, D W, Liu, V W S, To, R M Y, Chiu, P M, Lee, W Y W, Yao, K M, Cheung, A N Y, Ngan, H Y S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768441/
https://ncbi.nlm.nih.gov/pubmed/19755996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605316
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