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The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule

Tau inclusions are a prominent feature of many neurodegenerative diseases including Alzheimer's disease. Their accumulation in neurons as ubiquitinated filaments suggests a failure in the degradation limb of the Tau pathway. The components of a Tau protein triage system consisting of CHIP/Hsp70...

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Bibliografiske detaljer
Main Authors: Carrettiero, Daniel C., Hernandez, Israel, Neveu, Pierre, Papagiannakopoulos, Thales, Kosik, Kenneth S.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768429/
https://ncbi.nlm.nih.gov/pubmed/19228967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4660-08.2009
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