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Missense Polymorphisms in the Adenomatous Polyposis Coli Gene and Colorectal Cancer Risk
PURPOSE: Whereas truncating germline mutations of the adenomatous polyposis coli (APC) gene give rise to familial adenomatous polyposis, missense polymorphisms of APC may confer a weaker risk for colorectal cancer. METHODS: We sequenced the entire open reading frame of the APC gene and tested for tw...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768068/ https://ncbi.nlm.nih.gov/pubmed/18612690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10350-008-9356-7 |
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