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Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis
AIM: Increased production of cytokines and chemokines in serum and tissues upon oxidative stress caused by severe systemic infections are the major cause of sepsis. Aldose reductase (AR) known to mediate oxidative stress- induced NF-κB activation and transcription of cytokines and chemokines are the...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2767443/ https://ncbi.nlm.nih.gov/pubmed/19660963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2009.07.004 |
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