Effective Activation Alleviates the Replication Block of CCR5-tropic HIV-1 in Chimpanzee CD4+ Lymphocytes

Human immunodeficiency virus type 1 (HIV-1) originated in chimpanzees; yet, several previous studies have shown that primary HIV-1 isolates replicate poorly in chimpanzee CD4+ T lymphocytes in vitro and in vivo. The reasons for this apparent restriction are not understood. Here, we describe a new ac...

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Detalhes bibliográficos
Main Authors: Decker, Julie M., Zammit, Kenneth P., Easlick, Juliet L., Santiago, Mario L., Bonenberger, Denise, Hahn, Beatrice H., Kutsch, Olaf, Bibollet-Ruche, Frederic
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767406/
https://ncbi.nlm.nih.gov/pubmed/19748647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.08.027
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