Gefitinib–phenytoin interaction is not correlated with the (14)C-erythromycin breath test in healthy male volunteers

AIMS: We aimed to describe the pharmacokinetic interaction between phenytoin, a potent CYP3A4 and P-glycoprotein (P-gp) (ABCB1) inducer, and gefitinib, a CYP3A4, CYP2D6 and P-gp substrate. METHODS: An open-label, randomized, two-phase crossover study was conducted. Eighteen healthy male volunteers (...

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Bibliografiska uppgifter
Huvudupphovsmän: Chhun, Stephanie, Verstuyft, Celine, Rizzo-Padoin, Nathalie, Simoneau, Guy, Becquemont, Laurent, Peretti, Ilana, Swaisland, Alan, Wortelboer, Robert, Bergmann, Jean Francois, Mouly, Stephane
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 2009
Ämnen:
Drug Metabolism
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767287/
https://ncbi.nlm.nih.gov/pubmed/19694743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03438.x
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