Effect of widely used combinations of antiretroviral therapy on liver CYP3A4 activity in HIV-infected patients

AIMS: To evaluate the effects of combined antiretroviral drugs (HAART) on liver CYP3A4 activity using the [(14)C-N-methyl]-erythromycin breath test (ERMBT). METHODS: HIV-infected patients (31 women, 30 men) with mean (± SD) age of 38 ± 9 years were enrolled and underwent complete clinical and labora...

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Main Authors: Mouly, Stéphane, Rizzo-Padoin, Nathalie, Simoneau, Guy, Verstuyft, Céline, Aymard, Guy, Salvat, Cécile, Mahé, Isabelle, Bergmann, Jean-François
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2006
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885090/
https://ncbi.nlm.nih.gov/pubmed/16842395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02637.x
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