The Cerebral Cavernous Malformation signaling pathway promotes vascular integrity via Rho GTPases

Cerebral cavernous malformation (CCM) is a common vascular dysplasia that affects both systemic and CNS blood vessels. Loss of function mutations in the CCM2 gene cause CCM. Here we show that targeted disruption of Ccm2 in mice results in failed lumen formation and early embryonic death through an e...

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Main Authors: Whitehead, Kevin J., Chan, Aubrey C., Navankasattusas, Sutip, Koh, Wonshill, London, Nyall R., Ling, Jing, Mayo, Anne H., Drakos, Stavros G., Jones, Christopher A., Zhu, Weiquan, Marchuk, Douglas A., Davis, George A., Li, Dean Y.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767168/
https://ncbi.nlm.nih.gov/pubmed/19151728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1911
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