Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

Cerebral cavernous malformations (CCMs) are a common type of vascular malformation in the brain that are a major cause of hemorrhagic stroke. This condition has been independently linked to 3 separate genes: Krev1 interaction trapped (KRIT1), Cerebral cavernous malformation 2 (CCM2), and Programmed...

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Bibliografiska uppgifter
Huvudupphovsmän: Chan, Aubrey C., Drakos, Stavros G., Ruiz, Oscar E., Smith, Alexandra C.H., Gibson, Christopher C., Ling, Jing, Passi, Samuel F., Stratman, Amber N., Sacharidou, Anastasia, Revelo, M. Patricia, Grossmann, Allie H., Diakos, Nikolaos A., Davis, George E., Metzstein, Mark M., Whitehead, Kevin J., Li, Dean Y.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083782/
https://ncbi.nlm.nih.gov/pubmed/21490399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44393
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