ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation

A disintegrin and metalloproteinase-17 (ADAM17) is involved in proteolytic ectodomain shedding of several membrane-bound growth factors and cytokines. The expression and activity of ADAM17 increase under some pathological conditions such as stroke and glioma. ADAM17 promotes neural progenitor cell m...

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Bibliographic Details
Main Authors: Zheng, Xuguang, Jiang, Feng, Katakowski, Mark, Zhang, Zheng Gang, Lu, Qing-e, Chopp, Michael
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766867/
https://ncbi.nlm.nih.gov/pubmed/19395875
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