Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia

BACKGROUND: Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma. In this study, we investigated whether Sp1 transcription factor induces ADAM17 and/or contributes t...

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Autors principals: Szalad, Alexandra, Katakowski, Mark, Zheng, Xuguang, Jiang, Feng, Chopp, Michael
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758847/
https://ncbi.nlm.nih.gov/pubmed/19772640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-28-129
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