Mechanisms of Toll-Like Receptor 4 (TLR4)-Mediated Inflammation After Cold Ischemia/Reperfusion in the Heart

BACKGROUND: TLR4 signaling mediates early inflammation after cold I/R. We hypothesized that the TLR4 co-receptor CD14, the intracellular adaptor proteins MyD88 and TRIF would be required for cold I/R induced inflammation. HMGB1 is a putative endogenous activator of TLR4. Therefore, we also assessed...

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Autori principali: Kaczorowski, David J., Nakao, Atsunori, Vallabhaneni, Raghuveer, Mollen, Kevin P., Sugimoto, Ryujiro, Kohmoto, Junichi, Zuckerbraun, Brian S., McCurry, Kenneth, Billiar, Timothy R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766805/
https://ncbi.nlm.nih.gov/pubmed/19461481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3181a36e5e
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