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Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung
BACKGROUND: Allergic asthma results from inappropriate Th2-mediated inflammation. Both IL-4 and IL-13 contribute to asthma pathogenesis, but IL-4 predominantly drives Th2 induction, while IL-13 is necessary and sufficient for allergen-induced AHR and goblet cell hyperplasia. Although these 2 cytokin...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2766779/ https://ncbi.nlm.nih.gov/pubmed/19249085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2009.01.003 |
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