Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung

BACKGROUND: Allergic asthma results from inappropriate Th2-mediated inflammation. Both IL-4 and IL-13 contribute to asthma pathogenesis, but IL-4 predominantly drives Th2 induction, while IL-13 is necessary and sufficient for allergen-induced AHR and goblet cell hyperplasia. Although these 2 cytokin...

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Bibliographische Detailangaben
Hauptverfasser: Lewis, Christina C., Aronow, Bruce, Hutton, John, Santeliz, Joanna, Dienger, Krista, Herman, Nancy, Finkelman, Fred D., Wills-Karp, Marsha
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766779/
https://ncbi.nlm.nih.gov/pubmed/19249085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2009.01.003
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