Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease

Alloreactive donor cytolytic T lymphocytes play a critical role in pathophysiology of acute graft-versus-host disease (GVHD). As GVHD progression involves tumor necrosis factor superfamily receptor activation, and as apoptotic signaling for some tumor necrosis factor superfamily receptors might invo...

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Autores principales: Rotolo, Jimmy A., Stancevic, Branka, Lu, Sydney X., Zhang, Jianjun, Suh, David, King, Christopher G., Kappel, Lucy W., Murphy, George F., Liu, Chen, Fuks, Zvi, van den Brink, Marcel R., Kolesnick, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766684/
https://ncbi.nlm.nih.gov/pubmed/19666872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-191148
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