Statins Block Calcific Nodule Formation of Valvular Interstitial Cells by Inhibiting α-Smooth Muscle Actin Expression

OBJECTIVE: Calcific aortic stenosis, characterized by excessive fibrosis and deposition of bone-like calcified tissue, affects roughly 2–3% of the US population over 65. Recent studies have suggested that statins have a positive effect on the progression of aoritic stenosis, likely due to their abil...

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Bibliographic Details
Main Authors: Benton, Julie A., Kern, Hanna B., Leinwand, Leslie A., Mariner, Peter D., Anseth, Kristi S.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766347/
https://ncbi.nlm.nih.gov/pubmed/19679827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.195271
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