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Analysis of Synthetic Lethality Reveals Genetic Interactions Between the GTPase Snu114p and snRNAs in the Catalytic Core of the Saccharomyces cerevisiae Spliceosome

Conformational changes of snRNAs in the spliceosome required for pre-mRNA splicing are regulated by eight ATPases and one GTPase Snu114p. The Snu114p guanine state regulates U4/U6 unwinding during spliceosome activation and U2/U6 unwinding during spliceosome disassembly through the ATPase Brr2p. We...

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Detalhes bibliográficos
Main Authors: Frazer, Lily Novak, Lovell, Simon C., O'Keefe, Raymond T.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766312/
https://ncbi.nlm.nih.gov/pubmed/19620389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.107243
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