Determination of Adenosine A(1) Receptor Agonist and Antagonist Pharmacology Using Saccharomyces cerevisiae: Implications for Ligand Screening and Functional Selectivity

The budding yeast, Saccharomyces cerevisiae, is a convenient system for coupling heterologous G protein-coupled receptors (GPCRs) to the pheromone response pathway to facilitate empirical ligand screening and/or GPCR mutagenesis studies. However, few studies have applied this system to define GPCR-G...

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Detalhes bibliográficos
Main Authors: Stewart, Gregory D., Valant, Celine, Dowell, Simon J., Mijaljica, Dalibor, Devenish, Rodney J., Scammells, Peter J., Sexton, Patrick M., Christopoulos, Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Cellular and Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766231/
https://ncbi.nlm.nih.gov/pubmed/19641164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.158667
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