Interactions between Cyclic Nucleotide Phosphodiesterase 11 Catalytic Site and Substrates or Tadalafil and Role of a Critical Gln-869 Hydrogen Bond

Poor understanding of the topography of cyclic nucleotide (CN) phosphodiesterase (PDE) catalytic sites compromises development of potent, selective inhibitors for therapeutic use. In the X-ray crystal structures of the catalytic domains of some PDEs, an invariant glutamine hydrogen bonds with groups...

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Detaylı Bibliyografya
Asıl Yazarlar: Weeks, James L., Corbin, Jackie D., Francis, Sharron H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2009
Konular:
Cellular and Molecular
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766220/
https://ncbi.nlm.nih.gov/pubmed/19641165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.156935
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