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Practical Aspects of in Vivo Detection of Neuropeptides by Microdialysis Coupled Off-Line to Capillary LC with Multi-stage MS
A method using capillary LC-MS3 to determine endogenous opioid peptides in microdialysis samples collected in vivo was developed, validated, and applied to measurements in the rat striatum. Peptides in dialysate rapidly degraded when stored at room temperature or −80 °C. Adding acetic acid to a fina...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765559/ https://ncbi.nlm.nih.gov/pubmed/19196160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac802391b |
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