Single-stranded oligonucleotide-mediated in vivo gene repair in the rd1 retina

PURPOSE: The aim of this study was to test whether oligonucleotide-targeted gene repair can correct the point mutation in genomic DNA of PDE6b(rd1) (rd1) mouse retinas in vivo. METHODS: Oligonucleotides (ODNs) of 25 nucleotide length and complementary to genomic sequence subsuming the rd1 point muta...

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Detalhes bibliográficos
Main Authors: Andrieu-Soler, Charlotte, Halhal, Mounia, Boatright, Jeffrey H., Padove, Staci A., Nickerson, John M., Stodulkova, Eva, Stewart, Rachael E., Ciavatta, Vincent T., Doat, Marc, Jeanny, Jean-Claude, de Bizemont, Therèse, Sennlaub, Florian, Courtois, Yves, Behar-Cohen, Francine
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765472/
https://ncbi.nlm.nih.gov/pubmed/17563719
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