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Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains
Reverse transcriptases from HIV-1 and MuLV respectively prefer Mg(2+ )and Mn(2+ )for their polymerase activity, with variable fidelity, on both RNA and DNA templates. The function of the RNase H domain with respect to these parameters is not yet understood. To evaluate this function, two chimeric en...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765437/ https://ncbi.nlm.nih.gov/pubmed/19814799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-6-159 |
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