Modified vaccinia virus Ankara can activate NF-κB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication

Modified vaccinia virus Ankara (MVA), which is a promising replication-defective vaccine vector, is unusual among the orthopoxviruses in activating NF-κB transcription factors in cells of several types. In human embryonic kidney (HEK 293T) cells, the MVA-induced depletion of IκBα required to activat...

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Detalhes bibliográficos
Main Authors: Lynch, Heather E., Ray, Caroline A., Oie, Katrina L., Pollara, Justin J., Petty, Ian T. D., Sadler, Anthony J., Williams, Bryan R. G., Pickup, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765328/
https://ncbi.nlm.nih.gov/pubmed/19596385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.06.012
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