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Increased glucose uptake and oxidation in mouse hearts prevents high fatty acid oxidation but causes cardiac dysfunction in diet-induced obesity

BACKGROUND: Shift of myocardial substrate preference has been observed in many chronic diseases such as diabetes and heart failure. This study was undertaken to elucidate the mechanisms underlying the chronic substrate switch in adult hearts and to determine the functional consequences of the switch...

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Detalhes bibliográficos
Main Authors: Yan, Jie, Young, Martin E., Cui, Lei, Lopaschuk, Gary D., Liao, Ronglih, Tian, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765220/
https://ncbi.nlm.nih.gov/pubmed/19451348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.832915
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