The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

Upon detection of antigen, CD4(+) T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens. Alternative Th1 and Th2 cell fates are specified by the transcription factors T-bet and GATA-3, respectively. Only a handful of target genes...

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Detalles Bibliográficos
Autores principales: Jenner, Richard G., Townsend, Michael J., Jackson, Ian, Sun, Kaiming, Bouwman, Russell D., Young, Richard A., Glimcher, Laurie H., Lord, Graham M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764903/
https://ncbi.nlm.nih.gov/pubmed/19805038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909357106
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