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Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma

BACKGROUND: Clinical trials involving patients with glioblastoma (GBM) distinguish cohorts who are treated with enzyme-inducing anticonvulsants (EIAC). Such anticonvulsants induce hepatic P450 microsomal enzymes, which accelerate the metabolism of certain chemotherapy and molecular targeted agents....

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Bibliografski detalji
Glavni autori: Jaeckle, Kurt A., Ballman, Karla, Furth, Alfred, Buckner, Jan C.
Format: Artigo
Jezik:Inglês
Izdano: American Academy of Neurology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764724/
https://ncbi.nlm.nih.gov/pubmed/19822870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181bbfeca
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