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RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences
Potent antiviral RNAi can be induced by intracellular expression of short hairpin RNAs (shRNAs) and artificial microRNAs (miRNAs). Expression of shRNA and miRNA results in target mRNA degradation (perfect base pairing) or translational repression (partial base pairing). Although efficient inhibition...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764431/ https://ncbi.nlm.nih.gov/pubmed/19656954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp644 |
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