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In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses

To identify mutations that can arise in highly pathogenic A(H5N1) viruses under neuraminidase inhibitor selective pressure, two antigenically different strains were serially passaged with increasing levels of either oseltamivir or zanamivir. Under oseltamivir pressure, both A(H5N1) viruses developed...

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Detalhes bibliográficos
Main Authors: Hurt, Aeron C., Holien, Jessica K., Barr, Ian G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764219/
https://ncbi.nlm.nih.gov/pubmed/19651908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00334-09
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