Experimental Chemotherapy against Trypanosoma cruzi Infection Using Ruthenium Nitric Oxide Donors

The ruthenium NO donors of the group trans-[Ru(NO)(NH(3))(4)L](n+), where the ligand (L) is N-heterocyclic H(2)O, SO(3)(2−), or triethyl phosphite, are able to lyse Trypanosoma cruzi in vitro and in vivo. Using half-maximal (50%) inhibitory concentrations against bloodstream trypomastigotes (IC(50)(...

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Main Authors: Silva, Jean Jerley N., Pavanelli, Wander R., Pereira, José Clayston M., Silva, João S., Franco, Douglas W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764198/
https://ncbi.nlm.nih.gov/pubmed/19581464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00104-09
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