PROTEIN KINASE G PHOSPHORYLATES SOLUBLE GUANYLYL CYCLASE ON SERINE 64 AND INHIBITS ITS ACTIVITY

OBJECTIVE: Binding of nitric oxide (NO) to soluble guanylyl cyclase (sGC) leads to increased cGMP synthesis that activates cGMP-dependent protein kinase (PKG). Herein, we tested whether sGC activity is regulated by PKG. METHODS AND RESULTS: Overexpression of a constitutively active form of PKG (ΔPKG...

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Hlavní autoři: Zhou, Zongmin, Sayed, Nazish, Pyriochou, Anastasia, Roussos, Charis, Fulton, David, Beuve, Annie, Papapetropoulos, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763424/
https://ncbi.nlm.nih.gov/pubmed/18635821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.165043
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