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PROTEIN KINASE G PHOSPHORYLATES SOLUBLE GUANYLYL CYCLASE ON SERINE 64 AND INHIBITS ITS ACTIVITY
OBJECTIVE: Binding of nitric oxide (NO) to soluble guanylyl cyclase (sGC) leads to increased cGMP synthesis that activates cGMP-dependent protein kinase (PKG). Herein, we tested whether sGC activity is regulated by PKG. METHODS AND RESULTS: Overexpression of a constitutively active form of PKG (ΔPKG...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2763424/ https://ncbi.nlm.nih.gov/pubmed/18635821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.165043 |
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