Trypanosomes Have Six Mitochondrial DNA Helicases, with One Controlling Kinetoplast Maxicircle Replication

Kinetoplast DNA (kDNA), the trypanosome mitochondrial DNA, contains thousands of minicircles and dozens of maxicircles interlocked in a giant network. Remarkably, Trypanosoma brucei's genome encodes eight PIF1-like helicases, six of which are mitochondrial. We now show that TbPIF2 is essential...

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Autores principales: Liu, Beiyu, Wang, Jianyang, Yaffe, Nurit, Lindsay, Megan, Zhao, Zhixing, Zick, Aviad, Shlomai, Joseph, Englund, Paul T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763077/
https://ncbi.nlm.nih.gov/pubmed/19646907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.07.004
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