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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain
The hypothesis that amyloid-β (Aβ) peptides are the primary cause of Alzheimer's disease (AD) remains the best supported theory of AD pathogenesis. Yet, many observations are inconsistent with the hypothesis. Aβ peptides are generated when amyloid precursor protein (APP) is cleaved by presenili...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762847/ https://ncbi.nlm.nih.gov/pubmed/19837693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907652106 |
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