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Aging and excitotoxic stress exacerbate neural circuit reorganization in APP intracellular domain (AICD) transgenic mice
The cleavage of amyloid precursor protein (APP) by presenilins simultaneously generates amyloid-β (Aβ) and APP Intracellular Domain (AICD) peptides. Aβ plays a pivotal role in Alzheimer’s disease (AD) pathology and recently AICD was also shown to contribute to AD. Transgenic mice overexpressing AICD...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928862/ https://ncbi.nlm.nih.gov/pubmed/20493588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.04.020 |
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