Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases Radioresistance In Vitro and In Vivo

To determine whether increased mitochondrially localized catalase was radioprotective, a human catalase transgene was cloned into a small pSVZeo plasmid and localized to the mitochondria of 32D cl 3 cells by adding the mitochondrial localization sequence of MnSOD (mt-catalase). The cell lines 32D-Ca...

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Bibliographic Details
Main Authors: Epperly, Michael W., Melendez, J. A., Zhang, Xichen, Nie, Suhua, Pearce, Linda, Peterson, James, Franicola, Darcy, Dixon, Tracy, Greenberger, Benjamin A., Komanduri, Paavani, Wang, Hong, Greenberger, Joel S.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762783/
https://ncbi.nlm.nih.gov/pubmed/19580494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1424.1
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