Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci

Objective. Five loci—the shared epitope (SE) of HLA-DRB1, the PTPN22 gene, a locus on 6q23, the STAT4 gene and a locus mapping to the TRAF1/C5 genetic region—have now been unequivocally confirmed as conferring susceptibility to RA. The largest single effect is conferred by SE. We hypothesized that c...

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Autori principali: McClure, Annie, Lunt, Mark, Eyre, Steve, Ke, Xiayi, Thomson, Wendy, Hinks, Anne, Bowes, John, Gibbons, Laura, Plant, Darren, Wilson, Anthony G., Marinou, Ioanna, Morgan, Ann W., Emery, Paul, Steer, Sophia, Hocking, Lynne J., Reid, David M., Wordsworth, Paul, Harrison, Pille, Worthington, Jane, Barton, Anne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
Soggetti:
Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762544/
https://ncbi.nlm.nih.gov/pubmed/19741008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kep272
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