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ErbB2/HER2/Neu resembles an autoinhibited invertebrate EGF receptor
The orphan receptor tyrosine kinase ErbB2 (HER2/Neu) transforms cells when overexpressed1, and is an important therapeutic target in human cancer2,3. Structural studies4,5 have suggested that the oncogenic (and ligand-independent) signalling properties of ErbB2 result from the absence of a key intra...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762480/ https://ncbi.nlm.nih.gov/pubmed/19718021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08297 |
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