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Dual Inhibitors of Phosphodiesterase-4 and Serotonin Reuptake
A new class of multi-target compounds was synthesized by linking a novel selective serotonin reuptake inhibitor (SSRI) to a PDE4 inhibitor. The new dual PDE4 inhibitor/SSRI showed antidepressant-like activity in the forced swim test in mice The SSRIs 14, 2-{5-[3-(5-fluoro-2-methoxy-phenyl)-ethyl]-te...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762440/ https://ncbi.nlm.nih.gov/pubmed/19256502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8010993 |
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