IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

During endoplasmic reticulum (ER) stress, homeostatic signaling through the unfolded protein response (UPR) augments ER protein-folding capacity. If homeostasis is not restored, the UPR triggers apoptosis. We found that the ER transmembrane kinase/endoribonuclease (RNase) IRE1α is a key component of...

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Main Authors: Han, Dan, Lerner, Alana G., Walle, Lieselotte Vande, Upton, John-Paul, Xu, Weihong, Hagen, Andrew, Backes, Bradley J., Oakes, Scott A., Papa, Feroz R.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762408/
https://ncbi.nlm.nih.gov/pubmed/19665977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.017
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