MEK Inhibitors Potentiate Dexamethasone Lethality in Acute Lymphoblastic Leukemia Cells through the Pro-apoptotic Molecule BIM

Glucocorticoids (GC) are common components of many chemotherapeutic regimens for lymphoid malignancies. GC-induced apoptosis involves an intrinsic mitochondria-dependent pathway. We and others have shown that BIM (BCL-2 interacting mediator of cell death), a BH3-only pro-apoptotic protein, is up-reg...

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Autores principales: Rambal, Anila A., Panaguiton, Zarah Liz G., Kramer, Lora, Grant, Steven, Harada, Hisashi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761998/
https://ncbi.nlm.nih.gov/pubmed/19404317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2009.80
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