Structural evidence for a programmed general base in the active site of a catalytic antibody

The crystal structure of the complex of a catalytic antibody with its cationic hapten at 1.9-Å resolution demonstrates that the hapten amidinium group is stabilized through an ionic pair interaction with the carboxylate of a combining-site residue. The location of this carboxylate allows it to act a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Golinelli-Pimpaneau, Béatrice, Gonçalves, Olivier, Dintinger, Thierry, Blanchard, Dominique, Knossow, Marcel, Tellier, Charles
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27617/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10963661/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.18.9892
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