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X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release

The x-ray structures of the unliganded esterase-like catalytic antibody D2.3 and its complexes with a substrate analogue and with one of the reaction products are analyzed. Together with the structure of the phosphonate transition state analogue hapten complex, these crystal structures provide a com...

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Autors principals: Gigant, Benoît, Charbonnier, Jean-Baptiste, Eshhar, Zelig, Green, Bernard S., Knossow, Marcel
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC21519/
https://ncbi.nlm.nih.gov/pubmed/9223277
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