SELECTIVE, COMPETITIVE AND MECHANISM-BASED INHIBITORS OF HUMAN CYTOCHROME P450 2J2

Twenty five derivatives of the drugs terfenadine and ebastine have been designed, synthesized, and evaluated as inhibitors of recombinant human CYP2J2. Compound 14, which has an imidazole substituent, is a good non competitive inhibitor of CYP2J2 (IC(50) = 400 nM). It is not selective towards CYP2J2...

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Detaylı Bibliyografya
Asıl Yazarlar: LAFITE, Pierre, DIJOLS, Sylvie, ZELDIN, Darryl C., DANSETTE, Patrick M., MANSUY, Daniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761594/
https://ncbi.nlm.nih.gov/pubmed/17470359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.03.028
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