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SELECTIVE, COMPETITIVE AND MECHANISM-BASED INHIBITORS OF HUMAN CYTOCHROME P450 2J2
Twenty five derivatives of the drugs terfenadine and ebastine have been designed, synthesized, and evaluated as inhibitors of recombinant human CYP2J2. Compound 14, which has an imidazole substituent, is a good non competitive inhibitor of CYP2J2 (IC(50) = 400 nM). It is not selective towards CYP2J2...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2007
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761594/ https://ncbi.nlm.nih.gov/pubmed/17470359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.03.028 |
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