Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma

Elevated expression of HSP90 is observed in many tumor types and is associated with a limited clinical response. Targeting HSP90 using inhibitors such as 17-DMAG (17-desmethoxy-17-N,N-dimethylaminoethylaminogeldanamycin) has shown limited therapeutic success. HSP90 regulates the function of several...

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Autors principals: Ayrault, Olivier, Godeny, Michael D., Dillon, Christopher, Zindy, Frederique, Fitzgerald, Patrick, Roussel, Martine F., Beere, Helen M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761355/
https://ncbi.nlm.nih.gov/pubmed/19805107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902880106
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