pp60v-src transformation of rat cells but not chicken cells strongly correlates with low-affinity phosphopeptide binding by the SH2 domain.
Substrates critical for transformation by pp60v-src remain unknown, as does the precise role of the src homology 2 (SH2) domain in this process. To continue exploring the role of the SH2 domain in pp60v-src-mediated transformation, site-directed mutagenesis was used to create mutant v-src alleles pr...
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| Udgivet i: | Mol Biol Cell |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Cell Biology
1997
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC276133/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9168470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.8.5.843 |
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