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The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts

Specific guanine-rich sequence motifs in the human genome have considerable potential to form four-stranded structures known as G-quadruplexes or G4 DNA. The enrichment of these motifs in key chromosomal regions has suggested a functional role for the G-quadruplex structure in genomic regulation. In...

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Detalhes bibliográficos
Main Authors: Nakken, Sigve, Rognes, Torbjørn, Hovig, Eivind
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761265/
https://ncbi.nlm.nih.gov/pubmed/19617376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp590
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