Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not β-adrenergic stimulation in mouse cardiomyocytes

AIMS: β-Adrenergic augmentation of Ca(2+) sparks and cardiac contractility has been functionally linked to phosphorylation-dependent dissociation of FK506 binding protein 12.6 (FKBP12.6) regulatory proteins from ryanodine receptors subtype 2 (RYR2). We used FKBP12.6 null mice to test the extent to w...

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Detalhes bibliográficos
Main Authors: Zhang, Xu, Tallini, Yvonne N., Chen, Zheng, Gan, Lu, Wei, Bin, Doran, Robert, Miao, Lin, Xin, Hong-Bo, Kotlikoff, Michael I., Ji, Guangju
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761199/
https://ncbi.nlm.nih.gov/pubmed/19578067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp212
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