Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

The retinoblastoma protein (pRb) inhibits progression through the cell cycle. Although pRb is phosphorylated when G1 cyclin-dependent kinases (Cdks) are active, the mechanisms underlying pRb regulation are unknown. In vitro phosphorylation by cyclin D1/Cdk4 leads to inactivation of pRb in a microinj...

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Publié dans:	Mol Biol Cell
Auteurs principaux:	Connell-Crowley, L, Harper, J W, Goodrich, D W
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Cell Biology 1997
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC276080/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9190208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.8.2.287
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