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Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats

The present study examined the effect of a subchronic systemic administration of the glutamate metabotropic mGluR5 receptor antagonist MPEP on l-DOPA-induced dyskinesias and striatal gene expression in adult rats with a unilateral 6-OHDA lesion of dopamine neurons. The daily systemic administration...

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Detalhes bibliográficos
Main Authors: Yamamoto, Noriko, Soghomonian, Jean-Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760628/
https://ncbi.nlm.nih.gov/pubmed/19660528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2009.07.060
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