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In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation

Molecular mechanisms that regulate in situ activation of ryanodine receptors (RY) in different cells are poorly understood. Here we demonstrate that caffeine (10 mM) released Ca(2+) from the endoplasmic reticulum (ER) in the form of small spikes in only 14% of cultured fura-2 loaded beta cells from...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Islam, Md. Shahidul, Leibiger, Ingo, Leibiger, Barbara, Rossi, Daniela, Sorrentino, Vincenzo, Ekström, Tomas J., Westerblad, Håkan, Andrade, Francisco H., Berggren, Per-Olof
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1998
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27605/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600932/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6145
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